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Literature summary for 3.4.23.36 extracted from
- Myxobacteria antibiotic TA (myxovirescin) inhibits type II signal peptidase (2012), Antimicrob. Agents Chemother., 56, 2014-2021.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Myxobacteria antibiotic TA | TA inhibits pro-lipoprotein processing in whole cells, similar to globomycin, thus preventing outer membrane localization of lipoproteins LpoA and LpoB and blocking their essential interactions with PBP1A and PBP1B | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LspA | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | overexpression of signal peptides II specifically confers TA resistance to Escherichia coli | Escherichia coli |
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