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Literature summary for 3.4.23.3 extracted from

  • Narita, Y.; Oda, S.; Moriyama, A.; Takenaka, O.; Kageyama, T.
    Pepsinogens and pepsins from house musk shrew, Suncus murinus: Purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities (1997), J. Biochem., 121, 1010-1017.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
pepstatin 100 molar excess amount is needed for the complete inhibition of activity of pepsin C-1 and C-2 Suncus murinus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
pepsinogen C-2, 41000 Da, SDS-PAGE Suncus murinus
additional information
-
pepsinogen C-1, 39000 Da, SDS-PAGE Suncus murinus

Organism

Organism UniProt Comment Textmining
Suncus murinus
-
pepsin C-1 and C-2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification pepsinogen C-1 and C-2, each pepsinogen is converted to pepsin through an intermediate form under acidic conditions Suncus murinus
side-chain modification pepsinogen C-2 contains an Asn-linked carbohydrate chain of about 2000 Da Suncus murinus

Purification (Commentary)

Purification (Comment) Organism
pepsinogen C-1 and C-2 Suncus murinus

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
Suncus murinus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Suncus murinus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O pepsin C1 and C2 Suncus murinus ?
-
?
oxidized insulin B chain + H2O pepsin C-1 Suncus murinus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3
-
-
Suncus murinus

pH Range

pH Minimum pH Maximum Comment Organism
1.3 4.5 pH 1.3: about 75% of maximal activity, pH 4.5: about 35% of maximal activity, pepsin C-2 Suncus murinus
1.4 4.5 pH 1.4: about 90% of maximal activity, pH 4.5: about 40% of maximal activity, pepsin C-1 Suncus murinus