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Literature summary for 3.4.23.24 extracted from

  • Dostal, J.; Brynda, J.; Vankova, L.; Zia, S.R.; Pichova, I.; Heidingsfeld, O.; Lepik, M.
    Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis (2021), J. Enzyme Inhib. Med. Chem., 36, 914-921.
    View publication on PubMed
Search for more literature for 3.4.23.24

Crystallization (Commentary)

Crystallization (Comment) Organism
structures of Sapp1p complexed to four peptidomimetic inhibitors Candida parapsilosis

Inhibitors

Inhibitors Comment Organism Structure
BocValValPstAla(3R,4R)PstOMe
-
 Candida parapsilosis
BocValValPstAlaOMe
-
 Candida parapsilosis
BocValValPstAlaPstNH2
-
 Candida parapsilosis
BocValValPstAlaPstO
-
 Candida parapsilosis
pepstatin A
-
 Candida parapsilosis
ritonavir
-
 Candida parapsilosis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Candida parapsilosis
-
-

Organism

Organism UniProt Comment Textmining
Candida parapsilosis P32951 isoform SAPP!
-

Purification (Commentary)

Purification (Comment) Organism
purified from culture supernatant, using ion-exchange chromatography, followed by gel filtration Candida parapsilosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabcyl-Glu-His-Val-Lys-Leu-Val-Glu-EDANS + H2O
-
 Candida parapsilosis dabcyl-Glu-His-Val-Lys-Leu + Val-Glu-EDANS
-
 ?

Synonyms

Synonyms Comment Organism
SAPP1
-
 Candida parapsilosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000001
-
 BocValValPstAlaPstNH2 pH not specified in the publication, temperature not specified in the publication Candida parapsilosis
0.0000003
-
 pepstatin A pH not specified in the publication, temperature not specified in the publication Candida parapsilosis
0.0000004
-
 BocValValPstAla(3R,4R)PstOMe pH not specified in the publication, temperature not specified in the publication Candida parapsilosis
0.0000066
-
 BocValValPstAlaPstO pH not specified in the publication, temperature not specified in the publication Candida parapsilosis
0.0000146
-
 BocValValPstAlaOMe pH not specified in the publication, temperature not specified in the publication Candida parapsilosis
0.0019
-
 ritonavir pH not specified in the publication, temperature not specified in the publication Candida parapsilosis