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Literature summary for 3.4.23.24 extracted from

  • Skrbec, D.; Romeo, D.
    Inhibition of Candida albicans secreted aspartic protease by a novel series of peptidomimetics, also active on the HIV-1 protease (2002), Biochem. Biophys. Res. Commun., 297, 1350-1353.
    View publication on PubMed
Search for more literature for 3.4.23.24

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Phe-Ile-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl transition-state peptidomimetic TS-41 Candida albicans
acetyl-Trp-Phe-psi[OH-OH]-Phe-Trp-acetyl transition-state peptidomimetic TS-49 Candida albicans
acetyl-Trp-Ser-Phe-psi[OH-OH]-Phe-kynurenic acid transition-state peptidomimetic TS-57 Candida albicans
acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl transition-state peptidomimetic TS-43 Candida albicans
acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Val-acetyl transition-state peptidomimetic TS-75 Candida albicans
acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Val-Trp-acetyl transition-state peptidomimetic TS-42 Candida albicans
Arg-Ile-Phe-psi[CH2-NH]-Phe-Gln-Arg transition-state peptidomimetic TS-2 Candida albicans
kynurenic acid-Dtg-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid transition-state peptidomimetic TS-92 Candida albicans
kynurenic acid-Dtg-Phe-psi[OH-OH]-Phe-phenoxyacetic acid transition-state peptidomimetic TS-63 Candida albicans
kynurenic acid-Thr-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid transition-state peptidomimetic TS-93 Candida albicans
kynurenic acid-Thr-Phe-psi[OH-OH]-Phe-kynurenic acid transition-state peptidomimetic TS-59 Candida albicans
kynurenic acid-Val-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid transition-state peptidomimetic TS-94 Candida albicans
kynurenic acid-Val-Phe-psi(S,R,S)[OH]-Phe-Val-kynurenic acid transition-state peptidomimetic TS-91 Candida albicans
kynurenic acid-Val-Phe-psi[OH-OH]-Phe-Val-kynurenic acid best inhibitor; transition-state peptidomimetic TS-70 Candida albicans
Lys-Ile-Phe-psi[CH2-NH]-Phe-Gln-Arg transition-state peptidomimetic TS-23 Candida albicans
t-butoxylcarbonyl-Phe-psi[OH-OH]-Phe-Dtg-phenoxyacetic acid transition-state peptidomimetic TS-54 Candida albicans
t-butoxylcarbonyl-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl transition-state peptidomimetic TS-53 Candida albicans
Trp-Ile-Phe-psi[CH2-NH]-Phe-Gln-Trp transition-state peptidomimetic TS-10 Candida albicans
Xan-Dtg-Val-psi(S,R,S)[OH]-Val-Dtg-Xan transition-state peptidomimetic TS-90 Candida albicans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
 SDS-PAGE Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Candida albicans
-
 hydrolyzed protein
-
 ?
protein + H2O Candida albicans H12
-
 hydrolyzed protein
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida albicans H12
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from the culture medium of a virulent strain Candida albicans

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O
-
 Candida albicans ?
-
 ?
Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O
-
 Candida albicans H12 ?
-
 ?
Bovine serum albumin + H2O
-
 Candida albicans Hydrolyzed bovine serum albumin
-
 ?
Bovine serum albumin + H2O
-
 Candida albicans H12 Hydrolyzed bovine serum albumin
-
 ?
protein + H2O
-
 Candida albicans hydrolyzed protein
-
 ?
protein + H2O
-
 Candida albicans H12 hydrolyzed protein
-
 ?

Synonyms

Synonyms Comment Organism
SAP2
-
 Candida albicans
secreted aspartic protease
-
 Candida albicans