Protein Variants | Comment | Organism |
---|---|---|
L10I/G48V/I54V/V82A | multi-drug-resistant variant | Human immunodeficiency virus 1 |
V82T/I84V | multi-drug-resistant variant | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amprenavir | - |
Human immunodeficiency virus 1 | |
darunavir | - |
Human immunodeficiency virus 1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gag polyprotein + H2O | Human immunodeficiency virus 1 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | Q7SSI0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gag polyprotein + H2O | - |
Human immunodeficiency virus 1 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Human immunodeficiency virus 1 |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 PR | - |
Human immunodeficiency virus 1 |
HIV-1 protease | - |
Human immunodeficiency virus 1 |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is essential to the replication and invasion of HIV and is responsible for cleaving large polyprotein precursors Gag and releasing small structural proteins to help the assembly of infectious viral particles | Human immunodeficiency virus 1 |