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Literature summary for 3.4.23.16 extracted from
- Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance (2010), J. Virol., 84, 5368-5378.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Human immunodeficiency virus 1 |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D30N/L63P/N88D | mutations in drug-resistant clinical isolates | Human immunodeficiency virus 1 |
| I50V/A71V | mutations in drug-resistant clinical isolates | Human immunodeficiency virus 1 |
| L10I/G48V/I54V/L63P/V82A | mutations in drug-resistant clinical isolates | Human immunodeficiency virus 1 |
| L10I/L63P/A71V/G73S/I84V/L90M | mutations in drug-resistant clinical isolates | Human immunodeficiency virus 1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide | - |
Human immunodeficiency virus 1 |  |
| (2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamide | - |
Human immunodeficiency virus 1 | |
| (5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | - |
Human immunodeficiency virus 1 | |
| (5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | - |
Human immunodeficiency virus 1 | |
| (5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | - |
Human immunodeficiency virus 1 | |
| (5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | - |
Human immunodeficiency virus 1 | |
| (5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | - |
Human immunodeficiency virus 1 | |
| 3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamide | - |
Human immunodeficiency virus 1 | |
| 3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamide | - |
Human immunodeficiency virus 1 | |
| amprenavir | - |
Human immunodeficiency virus 1 | |
| atazanavir | - |
Human immunodeficiency virus 1 | |
| darunavir | - |
Human immunodeficiency virus 1 | |
| indinavir | - |
Human immunodeficiency virus 1 | |
| lopinavir | - |
Human immunodeficiency virus 1 | |
| N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamide | - |
Human immunodeficiency virus 1 | |
| N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | - |
Human immunodeficiency virus 1 | |
| N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | - |
Human immunodeficiency virus 1 | |
| N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | - |
Human immunodeficiency virus 1 | |
| N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | - |
Human immunodeficiency virus 1 | |
| N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamide | - |
Human immunodeficiency virus 1 | |
| N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamide | - |
Human immunodeficiency virus 1 | |
| nelfinavir | - |
Human immunodeficiency virus 1 | |
| ritonavir | - |
Human immunodeficiency virus 1 | |
| saquinavir | - |
Human immunodeficiency virus 1 | |
| tipranavir | - |
Human immunodeficiency virus 1 | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIV-1 protease | - |
Human immunodeficiency virus 1 |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000000008 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000001 | - |
tipranavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000000002 | - |
N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000004 | - |
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000005 | - |
lopinavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000005 | - |
darunavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000000006 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000006 | - |
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000008 | - |
darunavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000009 | - |
atazanavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000000014 | - |
tipranavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000000016 | - |
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000025 | - |
darunavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000000032 | - |
tipranavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000000039 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000039 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000004 | - |
lopinavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000000041 | - |
darunavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000000046 | - |
atazanavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000046 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000055 | - |
ritonavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000062 | - |
N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000063 | - |
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000063 | - |
N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.000000065 | - |
saquinavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000088 | - |
tipranavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000094 | - |
N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.0000001 | - |
amprenavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000000117 | - |
N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.00000012 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000015 | - |
amprenavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000016 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000018 | - |
indinavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.00000018 | - |
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000021 | - |
amprenavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000000227 | - |
N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000024 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000027 | - |
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000028 | - |
nelfinavir | wild-type protein | Human immunodeficiency virus 1 | |
| 0.00000031 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000033 | - |
darunavir | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.00000033 | - |
atazanavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000034 | - |
amprenavir | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.00000046 | - |
ritonavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000049 | - |
atazanavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.00000059 | - |
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000072 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000000724 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.000000724 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000073 | - |
indinavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000078 | - |
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000084 | - |
N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00000088 | - |
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.0000009 | - |
lopinavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000001 | - |
saquinavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000001 | - |
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.000001 | - |
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00000108 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.0000011 | - |
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.0000013 | - |
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.0000014 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.0000014 | - |
amprenavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000001713 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000018 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000019 | - |
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.00000192 | - |
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.0000021 | - |
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.0000023 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.0000028 | - |
ritonavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000003 | - |
ritonavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.0000034 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000035 | - |
nelfinavir | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.0000035 | - |
N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.0000035 | - |
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000042 | - |
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.000005 | - |
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000053 | - |
N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.0000061 | - |
lopinavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000007 | - |
N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000074 | - |
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000077 | - |
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0000125 | - |
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamide | I50V/A71V mutant protein | Human immunodeficiency virus 1 | |
| 0.000015 | - |
nelfinavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000019 | - |
nelfinavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000021 | - |
indinavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000024 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000029 | - |
N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000033 | - |
N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000034 | - |
indinavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000042 | - |
3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.00005 | - |
3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000053 | - |
(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000058 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | wild-type protein | Human immunodeficiency virus 1 | |
| 0.000063 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000066 | - |
3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.000078 | - |
saquinavir | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000079 | - |
3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.000085 | - |
3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00009 | - |
saquinavir | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000095 | - |
N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.00013 | - |
(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00013 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | D30N/L63P/N88D mutant protein | Human immunodeficiency virus 1 | |
| 0.00014 | - |
(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00014 | - |
3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.00026 | - |
3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00027 | - |
N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00036 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.000372 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.00038 | - |
3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.00067 | - |
(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
| 0.0013 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | L10I/G48V/I54V/L63P/V82A mutant protein | Human immunodeficiency virus 1 | |
| 0.0029 | - |
N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamide | L10I/L63P/A71V/G73S/I84V/L90M mutant protein | Human immunodeficiency virus 1 | |
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Release 2023.1 (January 2023)
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