Literature summary for 3.4.23.16 extracted from

Torbeev, V.Y.; Raghuraman, H.; Mandal, K.; Senapati, S.; Perozo, E.; Kent, S.B.
Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy (2009), J. Am. Chem. Soc., 131, 884-885.

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Protein Variants

Protein Variants	Comment	Organism
D25N	inactive	Human immunodeficiency virus 1

Inhibitors

Inhibitors	Comment	Organism	Structure
JG-365	-	Human immunodeficiency virus 1
KNI-272	-	Human immunodeficiency virus 1
KVS-1	-	Human immunodeficiency virus 1
MTV-101	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
wild-type and mutant protein prepared in nitroxide spin-labeled form by total chemical synthesis	Human immunodeficiency virus 1

Subunits

Subunits	Comment	Organism
homodimer	-	Human immunodeficiency virus 1

Synonyms

Synonyms	Comment	Organism
HIV-1 protease	-	Human immunodeficiency virus 1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000063	-	-	Human immunodeficiency virus 1	KVS-1

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Release 2023.1 (January 2023)