Literature summary for 3.4.23.16 extracted from

Lee, J.; Huh, M.S.; Kim, Y.C.; Hattori, M.; Otake, T.
Lignan, sesquilignans and dilignans, novel HIV-1 protease and cytopathic effect inhibitors purified from the rhizomes of Saururus chinensis (2010), Antiviral Res., 85, 425-428.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-pepstatin	-	Human immunodeficiency virus 1
manassantin A	-	Human immunodeficiency virus 1
saururin B	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Ile-Ser-NH2 + H2O	-	Human immunodeficiency virus 1	His-Lys-Ala-Arg-Val-Leu + (pNO2-Phe)-Glu-Ala-Ile-Ser-NH2	-	?

Synonyms

Synonyms	Comment	Organism
HIV-1 protease	-	Human immunodeficiency virus 1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00009	-	-	Human immunodeficiency virus 1	acetyl-pepstatin
0.0056	-	-	Human immunodeficiency virus 1	saururin B
0.0389	-	-	Human immunodeficiency virus 1	manassantin A

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Release 2023.1 (January 2023)