Protein Variants | Comment | Organism |
---|---|---|
A71T | in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B | Human immunodeficiency virus 1 |
D30N | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
G73S | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
I84V | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
K20M | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
K20R | in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B | Human immunodeficiency virus 1 |
K20T | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
L10V | in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B | Human immunodeficiency virus 1 |
L63P | in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B | Human immunodeficiency virus 1 |
L90M | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
M36I | in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B | Human immunodeficiency virus 1 |
additional information | comparison of the differences between subtypes B and F1 in the acquisition of major and minor protease inhibitor-associated resistance mutations and other polymorphisms in the protease gene. In untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B. In treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1. A higher proportion of subtype F1 than of subtype B strains containing other polymorphisms is observed. V82L mutation is present with increased frequency in isolates from children compared to isolates from adults infected with both subtypes | Human immunodeficiency virus 1 |
N88S | in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 | Human immunodeficiency virus 1 |
V77I | in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B | Human immunodeficiency virus 1 |
V82L | mutation is present with increased frequency in isolates from children compared to isolates from adults infected with both subtypes B and F1 | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
subtypes B and F1 | - |