Crystallization (Comment) | Organism |
---|---|
X-ray crystallographic analysis of HIV-1 protease in complex with transframe peptide FLREDLAF and the tripeptide EDL | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Arg-Arg | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Arg-Arg-Leu | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Arg-Arg-Phe | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Arg-Glu | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Arg-Glu-Asp | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Arg-Glu-Leu | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Arg-Leu-Ala-Phe | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Asp-Asp | - |
Human immunodeficiency virus 1 | |
Asp-Asp-Leu | - |
Human immunodeficiency virus 1 | |
Asp-Asp-Phe | - |
Human immunodeficiency virus 1 | |
Asp-Glu-Leu | - |
Human immunodeficiency virus 1 | |
Asp-Leu-Ala-Phe | - |
Human immunodeficiency virus 1 | |
FLREDLAF | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
GEDLAF | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Glu-Arg-Leu | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Glu-Arg-Leu-Ala | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Glu-Arg-Phe | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Glu-Asn-Leu | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Glu-Asp-Leu | - |
Human immunodeficiency virus 1 | |
Glu-Asp-Leu-Ala | - |
Human immunodeficiency virus 1 | |
Glu-Asp-Phe | - |
Human immunodeficiency virus 1 | |
Glu-Glu-Leu | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Glu-Lys-Phe | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 | |
Phe-Asp-Asp-Phe | with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-EA-Nle-NH2 | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
Glu-Asp-Phe | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.043 | - |
Asp-Asp-Phe | 25°C, pH 4.4 | Human immunodeficiency virus 1 | |
0.05 | - |
Glu-Asp-Leu | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.055 | - |
Phe-Asp-Asp-Phe | 25°C, pH 4.4 | Human immunodeficiency virus 1 | |
0.064 | - |
GEDLAF | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.098 | - |
FLREDLAF | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.14 | - |
Asp-Asp-Leu | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.16 | - |
Glu-Asp-Leu-Ala | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.23 | - |
Asp-Glu-Leu | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.27 | - |
Asp-Leu-Ala-Phe | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.31 | - |
Glu-Glu-Leu | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
0.97 | - |
Asp-Asp | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
2.01 | - |
Glu-Lys-Phe | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
3.07 | - |
Glu-Asn-Leu | 25°C, pH 4.25 | Human immunodeficiency virus 1 | |
3.36 | - |
Arg-Glu-Asp | 25°C, pH 4.25 | Human immunodeficiency virus 1 |