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Literature summary for 3.4.23.15 extracted from

  • Ferrario, C.M.
    Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control (2010), Life Sci., 86, 289-299.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine plasma renin activity is an independent predictor of morbidity and mortality in patients with hypertension Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
aliskiren direct renin inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens renin cleaves the Leu10-Leu11 bond angiotensin I + angiotensinogen propeptide
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
kidney enzymatically inactive prorenin is primarily synthesized in the kidney and accounts for 70% to 90% of the renin in the circulation Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O renin cleaves the Leu10-Leu11 bond Homo sapiens angiotensin I + angiotensinogen propeptide
-
?

Expression

Organism Comment Expression
Homo sapiens renin-angiotensin-aldosterone system blockade with angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers leads to exacerbated renin release through loss of negative-feedback inhibition down

General Information

General Information Comment Organism
metabolism renin is the first rate-limiting enzymatic step in the renin-angiotensin-aldosterone system pathway Homo sapiens