Application | Comment | Organism |
---|---|---|
medicine | plasma renin activity is an independent predictor of morbidity and mortality in patients with hypertension | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aliskiren | direct renin inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | Homo sapiens | renin cleaves the Leu10-Leu11 bond | angiotensin I + angiotensinogen propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
kidney | enzymatically inactive prorenin is primarily synthesized in the kidney and accounts for 70% to 90% of the renin in the circulation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | renin cleaves the Leu10-Leu11 bond | Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | renin-angiotensin-aldosterone system blockade with angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers leads to exacerbated renin release through loss of negative-feedback inhibition | down |
General Information | Comment | Organism |
---|---|---|
metabolism | renin is the first rate-limiting enzymatic step in the renin-angiotensin-aldosterone system pathway | Homo sapiens |