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Literature summary for 3.4.23.15 extracted from
- Application of direct renin inhibition to chronic kidney disease (2010), Cardiovasc. Drugs Ther., 24, 139-149.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aliskiren | direct renin inhibitor, aliskiren has the potential to reduce end organ damage in chronic kidney disease | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| secretory granule | renin is stored in secretory granules and is released in response to decreases in renal perfusion pressure, decreases in Cl- in the distal tubule fluid or increased sympathetic nerve stimulation via beta1-adrenoceptors | Homo sapiens | 30141 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | Homo sapiens | - |
angiotensin I + angiotensinogen propeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | - |
Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the intrarenal renin-angiotensin-aldosterone system is activated and plays a critical role in the pathogenesis of chronic kidney disease | Homo sapiens |
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Release 2023.1 (January 2023)
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