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Literature summary for 3.4.23.15 extracted from

  • Valencia, J.C.; Pacheco-Rodriguez, G.; Carmona, A.K.; Xavier, J.; Bruneval, P.; Riemenschneider, W.K.; Ikeda, Y.; Yu, Z.X.; Ferrans, V.J.; Moss, J.
    Tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis (2006), Am. J. Respir. Cell Mol. Biol., 35, 40-47.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
pharmacology the renin-angiotensin system is a potential target for lymphangioleiomyomatosis therapy Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens
-
 angiotensin I + angiotensinogen propeptide
-
 ?
additional information Homo sapiens tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis in LAM cells promotes cell proliferation and migration together with LAM nodules, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IYK8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LAM cell lymphangioleiomyomatosis cell Homo sapiens
-
lung
-
 Homo sapiens
-
nodule lymphangioleiomyomatosis nodule, i.e. LAM nodule Homo sapiens
-
smooth muscle-like cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity in lymphangioleiomyomatosis nodules and cells, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O
-
 Homo sapiens angiotensin I + angiotensinogen propeptide
-
 ?
additional information tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis in LAM cells promotes cell proliferation and migration together with LAM nodules, overview Homo sapiens ?
-
 ?