Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.B6 extracted from

  • Unciti-Broceta, J.D.; Maceira, J.; Morales, S.; Garcia-Perez, A.; Munoz-Torres, M.E.; Garcia-Salcedo, J.A.
    Nicotinamide inhibits the lysosomal cathepsin B-like protease and kills African trypanosomes (2013), J. Biol. Chem., 288, 10548-10557.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in Pichia pastoris Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
nicotinamide complete inhibition at 25 mM Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Trypanosoma brucei 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
x * 42000, recombinant zymogen, SDS-PAGE Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei Q6R7Z5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma brucei Z-Arg-Arg + 7-amino-4-methylcoumarin
-
?

Subunits

Subunits Comment Organism
? x * 42000, recombinant zymogen, SDS-PAGE Trypanosoma brucei

Synonyms

Synonyms Comment Organism
CatB
-
Trypanosoma brucei

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Trypanosoma brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Trypanosoma brucei

General Information

General Information Comment Organism
malfunction inhibition of the lysosomal cathepsin B-like protease blocks endocytosis causing cell death. Nicotinamide causes cytokinesis defects and cell cycle arrest at G2 phase Trypanosoma brucei
physiological function cathepsin B-like is a lysosomal protease responsible for degradation of host-derived growth factors, such as transferrin, in the bloodstream form of Trypanosoma brucei Trypanosoma brucei