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Literature summary for 3.4.22.B6 extracted from

  • Graber, S.; Maiti, S.; Halpain, S.
    Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines (2004), Neuropharmacology, 47, 706-713.
    View publication on PubMed
Search for more literature for 3.4.22.B6

Inhibitors

Inhibitors Comment Organism Structure
CA074Me specific inhibition Homo sapiens
cathepsin L inhibitor 1 has a lower inhibitory effct on cathepsin B-like protease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
synapse
-
 Homo sapiens 45202
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in lethal N-methyl-D-aspartate-induced collapse and F-actib loss of dendritic spines, sub-lethal ecitosis injury to dendrites can elicit loss or shrinkage of dendritic spines, specific enzyme inhibitors attenuate the effect, overview ?
-
 ?
myristoylated-alanine-rich C-kinase + H2O Homo sapiens specific degradation, the enzyme degrades the protein involved in actin cytoskeleton regulation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Homo sapiens
-
hippocampus neurons Homo sapiens
-
neuron hippocampal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in lethal N-methyl-D-aspartate-induced collapse and F-actib loss of dendritic spines, sub-lethal ecitosis injury to dendrites can elicit loss or shrinkage of dendritic spines, specific enzyme inhibitors attenuate the effect, overview Homo sapiens ?
-
 ?
myristoylated-alanine-rich C-kinase + H2O specific degradation, the enzyme degrades the protein involved in actin cytoskeleton regulation Homo sapiens ?
-
 ?
myristoylated-alanine-rich C-kinase substrate + H2O i.e. MARCKS, specific degradation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin B type protease
-
 Homo sapiens