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Literature summary for 3.4.22.B28 extracted from

  • Hata, S.; Abe, M.; Suzuki, H.; Kitamura, F.; Toyama-Sorimachi, N.; Abe, K.; Sakimura, K.; Sorimachi, H.
    Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense (2010), PLoS Genet., 6, e1001040.
    View publication on PubMed
Search for more literature for 3.4.22.B28

Protein Variants

Protein Variants Comment Organism
additional information generation of Capn8-/- mice, that are fertile and whose gastric mucosae appears normal. However, the mutant mice are susceptible to gastric mucosal injury induced by ethanol administration, and the Capn8-/- stomach shows significant decreases in both calpains 9 and 8, and the same was true for Capn9-/-. Effects of calpain 8 deficiency on mucous granule formation and secretion, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q91VA3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mucosa gastric Mus musculus
-
stomach calpain 8/nCL-2 is predominantly expressed in the gastrointestinal tract and is restricted to the gastric surface mucus cells in the stomach Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
additional information enzyme domain structure with prodomain, protease domain, C2-like domain, and 5EF-hand domain Mus musculus

Synonyms

Synonyms Comment Organism
calpain 8/nCL-2
-
 Mus musculus
additional information calpains constitute a superfamily of Ca2+-dependent cysteine proteases Mus musculus

General Information

General Information Comment Organism
physiological function calpain 8 is involved in vesicle trafficking between endoplasmic reticulum and Golgi. Calpain 8/nCL-2 is also involved in the mucosal defense against stress-induced gastropathies Mus musculus