Literature summary for 3.4.22.8 extracted from

Jozwiak, J.; Komar, A.; Jankowska, E.; Martirosian, G.
Determination of the cytotoxic effect of Clostridium histolyticum culture supernatant on HeLa cells in the presence of protease inhibitors (2005), FEMS Immunol. Med. Microbiol., 45, 137-142.

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Application

Application	Comment	Organism
medicine	influence of protease inhibitors aprotinin, phenylmethylsulfonyl fluoride, L-1-chloro-3-[4-tosylamido]-7-amino-2-heptanone, and chymostatin on toxicity of Clostridium histolyticum supernatant towards HeLa cells. Aprotinin has no effect, while the other inhibitors potentiate the cytotoxic activity of Clostridium histolyticum probybly by hindering the natural defense of cells. In addition, phenylmethylsulfonyl fluoride and L-1-chloro-3-[4-tosylamido]-7-amino-2-heptanone block clostripain enzymic activity	Hathewaya histolytica

Inhibitors

Inhibitors	Comment	Organism	Structure
L-1-chloro-3-[4-tosylamido]-7-amino-2-heptanone	complete inhibition	Hathewaya histolytica
phenylmethylsulfonyl fluoride	complete inhibition	Hathewaya histolytica

Organism

Organism	UniProt	Comment	Textmining
Hathewaya histolytica	-	-	-

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Release 2023.1 (January 2023)