Literature summary for 3.4.22.69 extracted from

Lim, L.; Gupta, G.; Roy, A.; Kang, J.; Srivastava, S.; Shi, J.; Song, J.
Structurally- and dynamically-driven allostery of the chymotrypsin-like proteases of SARS, Dengue and Zika viruses (2019), Prog. Biophys. Mol. Biol., 143, 52-66 .

Search for more literature for 3.4.22.69

Protein Variants

Protein Variants	Comment	Organism
N214A	the mutant shows reduced activity but still remains dimeric. Mutation inactivates the catalytic machinery by decoupling the network	Severe acute respiratory syndrome-related coronavirus
R298A	inactive monomeric mutant enzyme	Severe acute respiratory syndrome-related coronavirus

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome-related coronavirus	P0C6X7	human, i.e. SARS-CoV	-

Subunits

Subunits	Comment	Organism
dimer	the enzyme is only active in the dimeric form	Severe acute respiratory syndrome-related coronavirus

Synonyms

Synonyms	Comment	Organism
coronavirus 3C-like protease	-	Severe acute respiratory syndrome-related coronavirus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)