Application | Comment | Organism |
---|---|---|
drug development | coronavirus main protease (M(pro)) represents an attractive drug target for antiviral therapy of coronavirus infections, including severe acute respiratory syndrome (SARS) | Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the low inhibition potencies of known covalently interacting inhibitors may, at least in part, be attributed to insufficient fostering of the proton-transfer reaction | Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
SARS CoV | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme shows a substrate-induced catalytic mechanism that further enhances its substrate specificity, overview | Severe acute respiratory syndrome-related coronavirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
coronavirus M(pro) | - |
Severe acute respiratory syndrome-related coronavirus |
coronavirus main protease | - |
Severe acute respiratory syndrome-related coronavirus |
SARS-CoV main protease | - |
Severe acute respiratory syndrome-related coronavirus |
General Information | Comment | Organism |
---|---|---|
additional information | substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the enzyme, overview | Severe acute respiratory syndrome-related coronavirus |
physiological function | the activity of the enzyme toward specific viral protein substrates is required for efficient viral replication | Severe acute respiratory syndrome-related coronavirus |