Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-methoxyquinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
4-benzyloxy-3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
4-benzyloxy-3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
4-benzyloxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
4-hydroxy-3-[1-(4-hydroxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
4-hydroxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | - |
Severe acute respiratory syndrome-related coronavirus | |
5,7-dichloro-4-hydroxy-3-[1-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-1H-quinolin-2-one | - |
Severe acute respiratory syndrome-related coronavirus | |
5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Severe acute respiratory syndrome-related coronavirus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Dabcyl-KTSAVLQ + SGFRKME-EDANS | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C-like protease | - |
Severe acute respiratory syndrome-related coronavirus |
3CL protease | - |
Severe acute respiratory syndrome-related coronavirus |
3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-methoxyquinolin-2-(1H)one | |
0.01 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one | |
0.01 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-benzyloxy-3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-benzyloxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-benzyloxy-3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-hydroxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-hydroxy-3-[1-(4-hydroxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one | |
0.0125 | - |
in 10 mM HEPES at pH 7.5, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 5,7-dichloro-4-hydroxy-3-[1-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-1H-quinolin-2-one |