Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1,5-dihydro-2H-pyrrol-2-one | competitive inhibitor, 61.36% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus | |
4-([[4-cyclohexyl-5-(naphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)-1,3-thiazol-2-amine | competitive inhibitor, 58.23% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus | |
4-[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(3-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one | competitive inhibitor, 49.14% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus | |
N-(furan-2-ylmethyl)-2-[[5-(morpholin-4-yl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8-yl]sulfanyl]acetamide | competitive inhibitor, 53.27% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus | |
N-[(1E)-3-[(2E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinyl]-3-oxo-1-phenylprop-1-en-2-yl]benzamide | competitive inhibitor, 56.11% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus | |
N-[(1Z)-3-[[3-(dimethylamino)propyl]amino]-1-[5-(2-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide | competitive inhibitor, 81.43% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus | |
N-[(1Z)-3-[[3-(dimethylamino)propyl]amino]-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide | competitive inhibitor, 82.59% inhibition at 0.1 mM | Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Dabcyl-KTSAVLQ + SGFRKME-EDANS | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C-like protease | - |
Severe acute respiratory syndrome-related coronavirus |
3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03857 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | N-[(1Z)-3-[[3-(dimethylamino)propyl]amino]-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide | |
0.04139 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | N-[(1Z)-3-[[3-(dimethylamino)propyl]amino]-1-[5-(2-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide | |
0.05835 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-([[4-cyclohexyl-5-(naphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)-1,3-thiazol-2-amine | |
0.06279 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1,5-dihydro-2H-pyrrol-2-one | |
0.07709 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | N-[(1E)-3-[(2E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinyl]-3-oxo-1-phenylprop-1-en-2-yl]benzamide | |
0.09072 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | N-(furan-2-ylmethyl)-2-[[5-(morpholin-4-yl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8-yl]sulfanyl]acetamide | |
0.1014 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 4-[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(3-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one |