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Literature summary for 3.4.22.69 extracted from

  • Shao, Y.M.; Yang, W.B.; Kuo, T.H.; Tsai, K.C.; Lin, C.H.; Yang, A.S.; Liang, P.H.; Wong, C.H.
    Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease (2008), Bioorg. Med. Chem., 16, 4652-4660.
    View publication on PubMed
Search for more literature for 3.4.22.69

Inhibitors

Inhibitors Comment Organism Structure
3-(N-L-gamma-Glu-L-Ala)-1,1,1-trifluoropropan-2-one
-
 Severe acute respiratory syndrome-related coronavirus
3-[N-(N-benzyloxycarbonyl-L-Leu)]-4-phenyl-1,1,1-trifluorobutan-2-one
-
 Severe acute respiratory syndrome-related coronavirus
3-[N-(N-benzyloxycarbonyl-L-Phe)]-4-phenyl-1,1,1-trifluorobutan-2-one
-
 Severe acute respiratory syndrome-related coronavirus
3-[N-(N-tert-butoxycarbonyl)-L-Leu]-1,1,1-trifluorobutan-2-one
-
 Severe acute respiratory syndrome-related coronavirus
3-[N-[N-benzyloxycarbonyl-L-Ala-L-Val-L-Leu]]-4-phenyl-1,1,1-trifluorobutan-2-one
-
 Severe acute respiratory syndrome-related coronavirus
3-[N-[N-decanoyl-L-Leu]]-4-phenyl-1,1,1-trifluorobutan-2-one
-
 Severe acute respiratory syndrome-related coronavirus
3-{N-[N-tert-butoxycarbonyl-L-gamma-Glu(OtBu)-L-Ala]}-1,1,1-trifluoropropan-2-one
-
 Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus
-
-
-

Synonyms

Synonyms Comment Organism
SARS-CoV 3CL protease
-
 Severe acute respiratory syndrome-related coronavirus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
-
 Severe acute respiratory syndrome-related coronavirus 3-[N-[N-benzyloxycarbonyl-L-Ala-L-Val-L-Leu]]-4-phenyl-1,1,1-trifluorobutan-2-one
0.015
-
-
 Severe acute respiratory syndrome-related coronavirus 3-[N-(N-benzyloxycarbonyl-L-Leu)]-4-phenyl-1,1,1-trifluorobutan-2-one
0.02
-
-
 Severe acute respiratory syndrome-related coronavirus 3-[N-(N-benzyloxycarbonyl-L-Phe)]-4-phenyl-1,1,1-trifluorobutan-2-one
0.04
-
-
 Severe acute respiratory syndrome-related coronavirus 3-[N-(N-tert-butoxycarbonyl)-L-Leu]-1,1,1-trifluorobutan-2-one
0.04
-
-
 Severe acute respiratory syndrome-related coronavirus 3-[N-[N-tert-butoxycarbonyl-L-gamma-Glu(OtBu)-L-Ala]]-1,1,1-trifluoropropan-2-one
0.05
-
-
 Severe acute respiratory syndrome-related coronavirus 3-(N-L-gamma-Glu-L-Ala)-1,1,1-trifluoropropan-2-one
0.05
-
-
 Severe acute respiratory syndrome-related coronavirus 3-[N-[N-decanoyl-L-Leu]]-4-phenyl-1,1,1-trifluorobutan-2-one