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Literature summary for 3.4.22.68 extracted from
- Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2 (2015), J. Biol. Chem., 290, 22678-22685 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | O42957 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ulp1 | - |
Schizosaccharomyces pombe |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in fission yeast lacking nucleoporin Nup132 (Sc/HuNUP133), Ulp1 is delocalized and can no longer antagonize sumoylation of the PIAS family SUMO E3 ligase, Pli1. Consequently, SUMO chain-modified Pli1 is targeted for proteasomal degradation by the concerted action of a SUMO-targeted ubiquitin ligase (STUbL) and Cdc48-Ufd1-Npl4 | Schizosaccharomyces pombe |
| physiological function | in fission yeast lacking nucleoporin Nup132, Ulp1 is delocalized and can no longer antagonize sumoylation of the PIAS family SUMO E3 ligase, Pli1. Pli1 is targeted for proteasomal degradation by the concerted action of a SUMO-targeted ubiquitin ligase (STUbL) and Cdc48-Ufd1-Npl4 | Schizosaccharomyces pombe |
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