Literature summary for 3.4.22.66 extracted from

Nakamura, K.; Someya, Y.; Kumasaka, T.; Ueno, G.; Yamamoto, M.; Sato, T.; Takeda, N.; Miyamura, T.; Tanaka, N.
A norovirus protease structure provides insights into active and substrate binding site integrity (2005), J. Virol., 79, 13685-13693.

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Application

Application	Comment	Organism
medicine	nonbacterial acute gastroenteritis and other diseases associated with viruses expressing 3Cpro, knowledge of the structure and previous mutagenesis study allows to correlate proteolysis and structure	Chiba virus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli BL21 (DE3)	Chiba virus

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion grown at 20°C, at 2.8 A resolution	Chiba virus

Organism

Organism	UniProt	Comment	Textmining
Chiba virus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
purified over chitin beads and by gel filtration	Chiba virus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Glu-Thr-Thr-Leu-Glu-Gly-Gly-Asp	model of an oligopeptide bound to CVP	Chiba virus	Glu-Thr-Thr-Leu-Glu + Gly-Gly-Asp	-	?

Synonyms

Synonyms	Comment	Organism
3C-like protease	-	Chiba virus
CVP	-	Chiba virus

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Release 2023.1 (January 2023)