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Literature summary for 3.4.22.65 extracted from

  • Gough, L.; Schulz, O.; Sewell, H.F.; Shakib, F.
    The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response (1999), J. Exp. Med., 190, 1897-1902.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cysteine the enzyme is completely dependent on preactivation with cysteine Dermatophagoides pteronyssinus

Inhibitors

Inhibitors Comment Organism Structure
E-64
-
Dermatophagoides pteronyssinus
iodoacetamide
-
Dermatophagoides pteronyssinus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Dermatophagoides pteronyssinus Der p 1 is the most immunodominant allergen involved in the expression of dust mite-specific immunoglobulin (Ig)E-mediated hypersensitivity. The proteolytic activity of Der p 1 is a major contributor to its allergenicity. Cysteine protease activity of Der p 1 enhances total IgE production ?
-
?

Organism

Organism UniProt Comment Textmining
Dermatophagoides pteronyssinus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
feces
-
Dermatophagoides pteronyssinus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD25 + H2O
-
Dermatophagoides pteronyssinus ?
-
?
additional information Der p 1 is the most immunodominant allergen involved in the expression of dust mite-specific immunoglobulin (Ig)E-mediated hypersensitivity. The proteolytic activity of Der p 1 is a major contributor to its allergenicity. Cysteine protease activity of Der p 1 enhances total IgE production Dermatophagoides pteronyssinus ?
-
?