Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-(acetyloxy)benzoic acid 4-(nitrooxymethyl)-phenyl ester | i.e. para-NO-ASA, activates proteolytic enzyme activation. The compund inhibits the proliferation and induces cell death in acute lymphoblastic leukemia cell lines and patient samples | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | silencer of death domain and caspase-10 are frequently over-expressed in ALL. Interfering with these proteins may provide another strategy for the treatment of this and potentially other cancers | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the enzyme is activated by proteoltic cleavage | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
acute lymphoblastic leukemia cell | overexpression | Homo sapiens | - |
LK-63 cell | - |
Homo sapiens | - |
NALM-6 cell | - |
Homo sapiens | - |
REH cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | apoptosis is dependent on caspase-10 in association with the formation of the death-inducing signaling complex (DISC) incorporating pro-caspase-10 and tumor necrosis factor receptor 1 (TNF-R1), the process is ligand-independent | Homo sapiens |