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Literature summary for 3.4.22.63 extracted from

  • Cisterne, A.; Baraz, R.; Khan, N.I.; Welschinger, R.; Basnett, J.; Fung, C.; Rizos, H.; Bradstock, K.F.; Bendall, L.J.
    Silencer of death domains controls cell death through tumour necrosis factor-receptor 1 and caspase-10 in acute lymphoblastic leukemia (2014), PLoS ONE, 9, e103383.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
2-(acetyloxy)benzoic acid 4-(nitrooxymethyl)-phenyl ester i.e. para-NO-ASA, activates proteolytic enzyme activation. The compund inhibits the proliferation and induces cell death in acute lymphoblastic leukemia cell lines and patient samples Homo sapiens

Application

Application Comment Organism
medicine silencer of death domain and caspase-10 are frequently over-expressed in ALL. Interfering with these proteins may provide another strategy for the treatment of this and potentially other cancers Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme is activated by proteoltic cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
acute lymphoblastic leukemia cell overexpression Homo sapiens
-
LK-63 cell
-
Homo sapiens
-
NALM-6 cell
-
Homo sapiens
-
REH cell
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function apoptosis is dependent on caspase-10 in association with the formation of the death-inducing signaling complex (DISC) incorporating pro-caspase-10 and tumor necrosis factor receptor 1 (TNF-R1), the process is ligand-independent Homo sapiens