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Literature summary for 3.4.22.63 extracted from

  • Muehlethaler-Mottet, A.; Flahaut, M.; Bourloud, K.B.; Nardou, K.; Coulon, A.; Liberman, J.; Thome, M.; Gross, N.
    Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis (2011), Cell Death Dis., 2, e125.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.63

Protein Variants

Protein Variants Comment Organism
additional information caspase-10 isoforms are transiently downregulated using siRNAs targeting all caspase-10 isoforms, or siRNAs specific for individual caspase-10 isoforms. Downregulation of individual or all caspase-10 isoforms in SH-EP cells does not affect TRAIL sensitivity Homo sapiens

General Stability

General Stability Organism
caspase-10B is a highly unstable caspase-10 isoform, while isozymes caspase-10A, -D and and -G are remarkably stable Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CrmA caspase-10 is more resistant than caspase-8, EC 3.4.22.61, to the caspase inhibitor Homo sapiens
Z-VAD-fluoromethylketone caspase-10 is more resistant than caspase-8, EC 3.4.22.61, to the caspase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland high expression level Homo sapiens
-
B-lymphoma cell
-
 Homo sapiens
-
BJAB cell
-
 Homo sapiens
-
JURKAT cell low expression level Homo sapiens
-
lymphocyte from peripheral blood, high expression level Homo sapiens
-
neuroblastoma cell low expression level Homo sapiens
-
SH-EP cell neuroblastoma cells Homo sapiens
-
SK-N-AS cell neuroblastoma cells Homo sapiens
-
SW-480 cell low expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-4-nitroanilide + H2O
-
 Homo sapiens DEVD + 4-nitroaniline
-
 ?

General Information

General Information Comment Organism
malfunction caspase-10 silencing in neuroblastoma is cell-type related. Downregulation of individual or all caspase-10 isoforms in SH-EP cells does not affect TRAIL sensitivity Homo sapiens
additional information isozymes caspase-10B and -10A/B are protected from CHX-mediated degradation by lactacystin treatment Homo sapiens
physiological function individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis in several tumour cell types. Distinct caspase-10 isoforms induce opposed apoptotic signals in NB cells. Isozymes caspase-10A and -10D strongly increase tumour necrosis factor-related apoptosis-inducing ligand, i.e. TRAIL, and FasL sensitivity, whereas caspase-10B or -10G have no effect or are weakly anti-apoptotic. The unique C-terminal end of caspase-10B is responsible for its degradation by the ubiquitin-proteasome pathway and for its lack of pro-apoptotic activity compared with caspase-10A and -10D. Functional comparison to caspase-8, EC 3.4.22.61, overview. Caspase-10A or -10D isoforms can substitute for caspase-8 in the initiation extrinsic apoptosis Homo sapiens