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Literature summary for 3.4.22.63 extracted from

  • Srinivasula, S.M.; Ahmad, M.; Fernandes-Almeri, T.; Liwack, G.; Alnemri, E.S.
    Molecular ordering of the Fas-apoptotic pathway: the fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteien proteases (1996), Proc. Natl. Acad. Sci. USA, 93, 14486-14491.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
proMch4 lacking the two N-terminal FADD-like domains is subcloned in the bacterial expression vector pET21b Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cowpox serpin CrmA poorly inhibited Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Mch4 mediates the CrmA-insensitive apoptotic pathways, such as the DNA-damaging agents and staurosporine pathways ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification proMch4 can autoprocess after Asp-219 and Asp-372 to generate the two subunits of the mature enzyme : P17, the large subunit and p12, the small subunit Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information broad specificity towards pro-aspartate-specific cysteine proteases Homo sapiens ?
-
 ?
additional information Mch4 mediates the CrmA-insensitive apoptotic pathways, such as the DNA-damaging agents and staurosporine pathways Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More proMch4 can autoprocess after Asp-219 and Asp-372 to generate the two subunits of the mature enzyme: P17, the large subunit and p12, the small subunit Homo sapiens