Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bcl-2 + H2O | Homo sapiens | - |
? | - |
? | |
BclxL + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A2780/CP cell | - |
Homo sapiens | - |
A2780/S cell | - |
Homo sapiens | - |
DLD-1 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
K-562/CP cell | - |
Homo sapiens | - |
K-562/S cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bcl-2 + H2O | - |
Homo sapiens | ? | - |
? | |
BclxL + H2O | - |
Homo sapiens | ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | siRNA Si Casp-9-1 efficiently inhibits caspase-9 expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | caspase-9 inactivation by specific siRNA restrains the cleavage of Bcl-2 and Bcl-xL, inhibition of caspase-9 also prevents the degradation of Bcl-2 and Bcl-xL | Homo sapiens |
metabolism | caspase-9 regulates Puma and caspase-3 activation in apoptosis in cancer cells | Homo sapiens |
physiological function | caspase-9 induces feedback apoptosis of the mitochondrion by the cleavage of antiapoptotic Bcl-2 and Bcl-xL. Caspase-9 mediates Puma activation in protein kinase inhibitor 7-hydroxystaurosporine UCN-01-induced apoptosis, UCN-01 triggers Puma-induced mitochondrial apoptosis pathway, p53-independent Puma induction is pivotal for the anticancer effects of UCN-01. Caspase-9 enhances Puma activation by cleaving Bcl-2 and Bcl-xL independent of caspase-3. Caspase-9 also directly activates caspase-3 and apoptosis | Homo sapiens |