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Literature summary for 3.4.22.62 extracted from

  • Brentnall, M.; Rodriguez-Menocal, L.; De Guevara, R.L.; Cepero, E.; Boise, L.H.
    Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis (2013), BMC Cell Biol., 14, 32.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.62

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inactive Bid + H2O Mus musculus cleavage at amino acid 59 active tBid + ?
-
 ?
pro-caspase-3 + H2O Mus musculus
-
 active caspase-3 + caspase-3 propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-
FL5.12 cell
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inactive Bid + H2O cleavage at amino acid 59 Mus musculus active tBid + ?
-
 ?
inactive Bid + H2O cleavage at amino acid 59. Substrate mutants BidD98A and BidD75A are cleaved by caspase-9, mutant BidD59A is not cleaved Mus musculus active tBid + ?
-
 ?
pro-caspase-3 + H2O
-
 Mus musculus active caspase-3 + caspase-3 propeptide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction introduction of a dominant negative Casp9 inhibits mitochondrial remodeling without affecting the release of cytochrome c Mus musculus
metabolism caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis, which is is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade is responsible for executing cell death following cytochrome c release. Caspase-9 is required for mitochondrial morphological changes and reactive oxygen species production by cleaving and activating Bid into tBid. After activation by caspase-9, caspase-3 inhibits reactive oxygen species production and is required for efficient execution of apoptosis, while effector caspase-7 is required for apoptotic cell detachment Mus musculus
physiological function caspase-9 is required for mitochondrial morphological changes and reactive oxygen species production by cleaving and activating Bid into tBid, it activates caspase-3 and is necessary to remodel the mitochondria during intrinsic apoptosis Mus musculus