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Literature summary for 3.4.22.62 extracted from

  • Jeong, H.S.; Choi, H.Y.; Lee, E.R.; Kim, J.H.; Jeon, K.; Lee, H.J.; Cho, S.G.
    Involvement of caspase-9 in autophagy-mediated cell survival pathway (2011), Biochim. Biophys. Acta, 1813, 80-90.
    View publication on PubMed
Search for more literature for 3.4.22.62

Activating Compound

Activating Compound Comment Organism Structure
additional information treatment with the NSAID FR122047 promotes apoptosis and caspase activation in MCF-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of caspase-9 expression by specific siRNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-LEHD-fluoromethylketone a caspase-9 inhibitor Homo sapiens
Z-VAD-fluoromethylketone a pan-caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poly (ADP-ribose) polymerase + H2O Homo sapiens i.e. PARP ?
-
 ?
procaspase-7 + H2O Homo sapiens
-
 caspase-7 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
LEDH-4-nitroanilide + H2O
-
 Homo sapiens LEDH + 4-nitroaniline
-
 ?
poly (ADP-ribose) polymerase + H2O i.e. PARP Homo sapiens ?
-
 ?
procaspase-7 + H2O
-
 Homo sapiens caspase-7 + ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of caspase-9 activity results in unexpected, marked enhancement of cell death, inhibition of caspase-9 blocks the autophagic process by modulating lysosomal pH and acid-dependent cathepsin activities and augments cell death due to blockage of cytoprotective autophagy. Knockdown of caspase-9 expression by specific siRNA causes increased susceptibility to NSAID FR122047-induced cell death Homo sapiens
additional information treatment with the NSAID FR122047 promotes apoptosis and caspase activation in MCF-7 cells Homo sapiens
physiological function involvement of caspase-9 in autophagy-mediated cell survival pathway Homo sapiens