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Literature summary for 3.4.22.62 extracted from

  • Mukherjee, J.J.; Gupta, S.K.; Kumar, S.
    Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase (2009), Mutat. Res., 661, 41-46.
    View publication on PubMed
Search for more literature for 3.4.22.62

Activating Compound

Activating Compound Comment Organism Structure
additional information treatment of HL-60 cells with 1 microM benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) elicits induction of caspase-9 activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cadmium anti-apoptotic cell survival function of cadmium, cadmium inhibits apoptosis induced by benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) at non-cytotoxic concentrations, 40% and 52% inhibition at 10 and 20 microM cadmium chloride, respectively Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ anti-apoptotic cell survival function of cadmium, cadmium inhibits apoptosis induced by benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) at non-cytotoxic concentrations, cadmium chloride pre-treatment of cells significantly inhibits caspase-9 activation in a dose dependent manner, 40% and 52% inhibition at 10 and 20 microM cadmium chloride, respectively Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P55211
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-

Source Tissue

Source Tissue Comment Organism Textmining
cortical collecting duct cell
-
 Homo sapiens
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fibroblast cell line human fibroblast GM03349 Homo sapiens
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HL-60 cell
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 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 protective effects of cadmium on apoptosis induced by benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), inhibition of BPDE-induced apoptosis by cadmium is associated with downregulation of caspase-9 activation, cadmium-induced inhibition of apoptosis associated with downregulation of caspase-9 activation, 40% and 52% inhibition of apoptosis after pre-treatment of cells with 10 and 20 microM cadmium chloride, respectively Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Leu-Glu-His-Asp-p-nitroanilide + H2O i.e. LEHD-pNA, caspase-9 activity determined, anti-apoptotic cell survival function of cadmium Homo sapiens acetyl-Leu-Glu-His-Asp + p-nitroaniline
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 caspase-9 activity determined at Homo sapiens