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Literature summary for 3.4.22.62 extracted from

  • Aprigliano, I.; Dudas, J.; Ramadori, G.; Saile, B.
    Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells (2008), Liver Int., 28, 546-557.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.62

Activating Compound

Activating Compound Comment Organism Structure
additional information atorvastatin induces apoptosis in vitro, dose dependent effect, first detectable after 20 h, increased activity of caspase-9 to 407% and of caspase-3 to 540% after treatment with atorvastatin and/or mevalonic acid (125 microM), with and without the kinase-activator U0126 (10 microM) Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information atorvastatin-mediated apoptosis of hepatic stellate cells (HSCs) can be bocked by co-treatment with mevalonic acid and U0126, an activator of the extracellular signal-regulated protein kinase (ERK1/2) Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Rattus norvegicus
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 ?
-
 ?
pro-caspase-3 + H2O Rattus norvegicus Wistar
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 ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 Wistar
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Rattus norvegicus Wistar
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 Wistar
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Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell primary cultures of, in vitro activation by atorvastatin, mevalonic acid and U0126, an activator of the extracellular signal-regulated protein kinase (ERK1/2) Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 atorvastatin induces apoptosis in hepatic stellate cells (HSCs), atorvastatin-mediated apoptosis is blocked by co-application of mevalonic acid and U0126, an activator of the extracellular signal-regulated protein kinase (ERK1/2), increased activity of caspase-9 to 407% and of caspase-3 to 540% in cells treated with atorvastatin, flow cytometry, laser-scanning microscopy, Western blot, electrophoresis mobility shift assay, pathway of apoptosis induced by atorvastatin in hepatic stellate cells (HSCs) summarized Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-caspase-3 + H2O
-
 Rattus norvegicus ?
-
 ?
pro-caspase-3 + H2O increased activity of caspase-9 to 407% and of caspase-3 to 540% after cell treatment with atorvastatin Rattus norvegicus ?
-
 ?
pro-caspase-3 + H2O
-
 Rattus norvegicus Wistar ?
-
 ?
pro-caspase-3 + H2O increased activity of caspase-9 to 407% and of caspase-3 to 540% after cell treatment with atorvastatin Rattus norvegicus Wistar ?
-
 ?