Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyloxycarbonyl-Ile-Glu-Thr-Asp-fluoromethylketone | - |
Cricetulus griseus | |
benzyloxycarbonyl-Leu-Glu-His-Asp-fluoromethylketone | - |
Cricetulus griseus | |
benzyloxycarbonyl-Val-Asp-Val-Ala-Asp-fluoromethylketone | - |
Cricetulus griseus | |
additional information | inhibition of caspase-9 enhances the viability of the CHO cells in both batch and fed-batch suspension cultures | Cricetulus griseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cricetulus griseus | caspase-9 is possibly involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | inhibition of caspase-9 enhances the viability of the CHO cells in both batch and fed-batch suspension cultures. Caspase-9 is possible involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells | Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Ile-Glu-Thr-Asp-p-nitroanilide + H2O | 13% of the activity with acetyl-Leu-Glu-His-Asp-p-nitroanilide | Cricetulus griseus | acetyl-Ile-Glu-Thr-Asp + p-nitroaniline | - |
? | |
acetyl-Leu-Glu-His-Asp-p-nitroanilide + H2O | - |
Cricetulus griseus | acetyl-Leu-Glu-His-Asp + p-nitroaniline | - |
? | |
acetyl-Trp-Glu-His-Asp-p-nitroanilide + H2O | 49% of the activity with acetyl-Leu-Glu-His-Asp-p-nitroanilide | Cricetulus griseus | acetyl-Trp-Glu-His-Asp + p-nitroaniline | - |
? | |
acetyl-Val-Glu-Ile-Asp-p-nitroanilide + H2O | 19% of the activity with acetyl-Leu-Glu-His-Asp-p-nitroanilide | Cricetulus griseus | acetyl-Val-Glu-Ile-Asp + p-nitroaniline | - |
? | |
additional information | caspase-9 is possibly involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells | Cricetulus griseus | ? | - |
? | |
additional information | no activity with acetyl-Asp-Glu-Val-Asp-p-nitroanilide and acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide | Cricetulus griseus | ? | - |
? |