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Literature summary for 3.4.22.62 extracted from

  • Furuta, K.; Nakayama, K.; Sugimoto, Y.; Ichikawa, A.; Tanaka, S.
    Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815 (2007), J. Biol. Chem., 282, 13438-13446.
    View publication on PubMed
Search for more literature for 3.4.22.62

Application

Application Comment Organism
medicine caspase-9 is a target for development of therapeutic approaches for histamine-related diseases Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Leu-Glu-His-Asp-fluoromethylketone
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine decarboxylase precursor + H2O Mus musculus in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of L-histidine decarboxylase, which is mediated by caspase-9 ?
-
 ?
L-histidine decarboxylase precursor + H2O Mus musculus BDF1 in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of L-histidine decarboxylase, which is mediated by caspase-9 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
P-815 cell mastocytoma Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine decarboxylase precursor + H2O
-
 Mus musculus ?
-
 ?
L-histidine decarboxylase precursor + H2O in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of L-histidine decarboxylase, which is mediated by caspase-9 Mus musculus ?
-
 ?
L-histidine decarboxylase precursor + H2O
-
 Mus musculus BDF1 ?
-
 ?
L-histidine decarboxylase precursor + H2O in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of L-histidine decarboxylase, which is mediated by caspase-9 Mus musculus BDF1 ?
-
 ?