additional information |
caspase-9S is a naturally occuring variant of caspase-9 that is missing most of the large subunit of caspase-9, including the catalytic site, but has the intact prodomain and small subunit. Caspase-9S does not show apoptotic activity in transfection analysis. Overexpression of caspase 9S inhibits apoptosis induced by caspase-9. Caspase-9S inhibits apoptosis induced by tumor necrosis factor alpha, TNF factor-related apoptosis-inducing ligand, Bax, or fas-associated death domain-containing protein as well as the combination of Apaf-1 and caspase-9 |
Homo sapiens |