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Literature summary for 3.4.22.61 extracted from

  • Huang, K.; Zhang, J.; ONeill, K.L.; Gurumurthy, C.B.; Quadros, R.M.; Tu, Y.; Luo, X.
    Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein Bid during TRAIL-induced apoptosis (2016), J. Biol. Chem., 291, 11843-11851 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BH3-only protein Bid + H2O Homo sapiens
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 ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
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-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BH3-only protein Bid + H2O
-
 Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function cleavage by caspase 8 and the subsequent association with the outer mitochondrial membrane are two critical events that activate BH3-only protein Bid during death receptor-mediated apoptosis Homo sapiens