Literature summary for 3.4.22.61 extracted from

Saavedra, E.; Del Rosario, H.; Brouard, I.; Quintana, J.; Estevez, F.
6-Benzyloxy-4-bromo-2-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis (2019), Chem. Biol. Interact., 298, 137-145 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
6'-benzyloxy-4-bromo-2'-hydroxychalcone	compound displays potent cytotoxic properties against human leukaemia cells U-937, HL-60, K-562, NALM-6 and MOLT-3. Application results in significant activation of caspase-8 after 24 h of treatment	Homo sapiens

Application

Application	Comment	Organism
medicine	compound 6'-benzyloxy-4-bromo-2'-hydroxychalcone displays potent cytotoxic properties against human leukaemia cells U-937, HL-60, K-562, NALM-6 and MOLT-3. Application results in significant activation of caspase-8 after 24 h of treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14790	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-
K-562 cell	-	Homo sapiens	-
MOLT-3 cell	-	Homo sapiens	-
NALM-6 cell	-	Homo sapiens	-
U-937 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)