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Literature summary for 3.4.22.61 extracted from

  • Li, X.; Zhao, Y.; Zhang, Y.; Du, N.; Ren, H.
    Tumor necrosis factor alpha stimulates Her-2 cleavage by activated caspase-8 (2012), Cell. Physiol. Biochem., 30, 889-897.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information tumor necrosis factor alpha stimulation results in a caspase-8-dependent Her-2 cleavage in MCF-7 breast adenocarcinoma cells defective for nuclear factor kappaB activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
HER-2 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast adenocarcinoma cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HER-2 + H2O
-
Homo sapiens ?
-
?
IEPD-7-amido-4-methylcoumarin + H2O
-
Homo sapiens IEPD + 7-amino-4-methylcoumarin
-
?