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Literature summary for 3.4.22.61 extracted from

  • O'Donnell, M.A.; Perez-Jimenez, E.; Oberst, A.; Ng, A.; Massoumi, R.; Xavier, R.; Green, D.R.; Ting, A.T.
    Caspase 8 inhibits programmed necrosis by processing CYLD (2011), Nat. Cell Biol., 13, 1437-1442.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.61

Protein Variants

Protein Variants Comment Organism
additional information transfection of wild-type Jurkat T cells with two different Casp8-targeting RNAi oligonucleotides leads to knockdown of caspase 8 Homo sapiens
additional information transfection of wild-type MEFs with two different Casp8-targeting RNAi oligonucleotides leads to knockdown of caspase 8 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CrmA inhibits caspase 8, while mutant CrmAD303A is unable to prevent cleavage of CYLD Homo sapiens
CrmA inhibits caspase 8, while mutant CrmAD303A is unable to prevent cleavage of CYLD Mus musculus
Z-VAD-fluoromethylketone
-
 Homo sapiens
Z-VAD-fluoromethylketone
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CYLD + H2O Homo sapiens key substrate processed by caspase 8 to block necrosis, CYLD is a key requirement for necrosis CYLDp25 + ?
-
 ?
CYLD + H2O Mus musculus key substrate processed by caspase 8 to block necrosis, CYLD is a key requirement for necrosis of L929 fibrosarcoma cells CYLDp25 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibrosarcoma cell
-
 Mus musculus
-
HEK-293 cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
L-929 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CYLD + H2O key substrate processed by caspase 8 to block necrosis, CYLD is a key requirement for necrosis Homo sapiens CYLDp25 + ?
-
 ?
CYLD + H2O key substrate processed by caspase 8 to block necrosis, CYLD is a key requirement for necrosis of L929 fibrosarcoma cells Mus musculus CYLDp25 + ?
-
 ?
CYLD + H2O caspase 8 directly cleaves CYLD after Asp 215, an Asp215 CYLD substitution mutant cannot be cleaved by caspase 8 Mus musculus CYLDp25 + ?
-
 ?
CYLD + H2O caspase 8 directly cleaves CYLD after Asp 215, an Asp215 CYLD substitution mutant cannot be cleaved by caspase 8 Homo sapiens CYLDp25 + ?
-
 ?

Synonyms

Synonyms Comment Organism
caspase 8
-
 Mus musculus
caspase 8
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction loss of caspase 8 prevents CYLD degradation, resulting in necrotic death. Mutation of the caspase 8 processing site on the substrate converts a pro-survival response to necrotic death without the need for caspase 8 inhibition Mus musculus
malfunction loss of caspase 8 prevents CYLD degradation, resulting in necrotic death. Mutation of the caspase 8 processing site on the substrate converts a pro-survival response to necrotic death without the need for caspase 8 inhibition Homo sapiens
physiological function caspase 8 inhibits programmed necrosis by processing CYLD. Suppression of necrotic cell death by caspase 8 requires its catalytic activity but not the autocleavage essential for apoptosis. CYLD is cleaved by caspase 8 to promote survival Mus musculus
physiological function caspase 8 inhibits programmed necrosis by processing CYLD. Suppression of necrotic cell death by caspase 8 requires its catalytic activity but not the autocleavage essential for apoptosis. CYLD is cleaved by caspase 8 to promote survival. TNF-treated caspase-8-sufficient Jurkat T cells dying by apoptosis but remain unchanged in the caspase-8-deficient cells dying by necrosis Homo sapiens