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Literature summary for 3.4.22.61 extracted from

  • Akagi, T.; Shimizu, K.; Takahama, S.; Iwasaki, T.; Sakamaki, K.; Endo, Y.; Sawasaki, T.
    Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling (2011), FEBS Lett., 585, 1835-1840.
    View publication on PubMed
Search for more literature for 3.4.22.61

Inhibitors

Inhibitors Comment Organism Structure
Z-IETD-fluoromethylketone
-
 Homo sapiens
Z-VAD-fluoromethylketone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane procaspase-8 is part of the trans-plasma membrane death-inducing signaling complex and is located on the cytosolic side. The activated enzyme is then released from the complex as caspase-8 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bid + H2O Homo sapiens i.e. BH3 interacting domain death agonist tBid + ?
-
 ?
caspase-3 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-21 + H2O Homo sapiens
-
 ? the CASP8-cleaved form of IL21R does not induce phosphorylation at Tyr705 of STAT3 ?
vezatin + H2O Homo sapiens cleaved at Asp655 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bid + H2O i.e. BH3 interacting domain death agonist Homo sapiens tBid + ?
-
 ?
carbonic anhydrase XIV + H2O cleaved at Asp53 Homo sapiens ?
-
 ?
caspase-3 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-21 + H2O
-
 Homo sapiens ? the CASP8-cleaved form of IL21R does not induce phosphorylation at Tyr705 of STAT3 ?
interleukin-21 + H2O cleaved at Asp344 Homo sapiens ?
-
 ?
additional information generation of an NCtagged sTMP library and screening for CASP8 substrates, CASP8-cleavable sTMPs in the sTMP library, overview. Determination of cleavage sites by amino acid sequencing, consensus-type sequences are X-E/Q-X-D;-G/S, with X being any amino acid Homo sapiens ?
-
 ?
vezatin + H2O cleaved at Asp655 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Casp8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function caspase-8 cleavage of the interleukin-21, IL-21, receptor is a negative feedback regulation of IL-21 signaling. Caspase-3 and the BH3 interacting domain death agonist, Bid, are cleaved by CASP8 as part of the apoptotic pathway Homo sapiens