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Literature summary for 3.4.22.61 extracted from

  • Kober, A.M.; Legewie, S.; Pforr, C.; Fricker, N.; Eils, R.; Krammer, P.H.; Lavrik, I.N.
    Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation (2011), Cell Death Dis., 2, e212.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.61

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification CD95 DISC-induced caspase-8 activity, mechanism, the long c-FLIP isoform, c-FLIPL, and the short c-FLIP isoform, c-FLIPR, inhibit caspase-8 processing at the DISC Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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General Information

General Information Comment Organism
metabolism mathematical modeling of CD95 DISC-mediated MAPK activation and apoptosis, overview. Quantitative dynamics of DED proteins, procaspase-8, and c-FLIP, which lead to caspase-8 activation and induction of apoptotic and non-apoptotic signaling pathways Homo sapiens
physiological function caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation. Stimulation of CD95/Fas/APO-1 results in the induction of both apoptotic and non-apoptotic signaling pathways. CD95 DISC-induced caspase-8 activity is important for the initiation of ERK1/2 and p38 MAPK activation, caspase-8 activation mechanism, overview. The long c-FLIP isoform, c-FLIPL, and the short c-FLIP isoform, c-FLIPR, inhibit MAPK induction by blocking caspase-8 processing at the DISC. Caspase-8 activity is also essential to MAPK activation in response to anti-APO-1 stimulation Homo sapiens