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BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Darvas, K.; Rosenberger, S.; Brenner, D.; Fritsch, C.; Gmelin, N.; Krammer, P.H.; Roesl, F.
    Histone deacetylase inhibitor-induced sensitization to TNFalpha/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression (2010), Int. J. Cancer, 127, 1384-1392.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cellular FLICE inhibitory protein
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens histone deacetylase inhibition leads to transcriptional suppression of cellular FLIP, which negatively regulates extrinsic apoptosis by preventing the recruitment of caspase-8 to the death-inducing signaling complex down