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Literature summary for 3.4.22.61 extracted from

  • Heo, S.K.; Yun, H.J.; Park, W.H.; Park, S.D.
    Rhein inhibits TNF-alpha-induced human aortic smooth muscle cell proliferation via mitochondrial-dependent apoptosis (2009), J. Vasc. Res., 46, 375-386.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
additional information procaspase-8 is cleaved to 41 and 43 kDA fragments for activation, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-IETD-fluoromethyl ketone a caspase-8-specific inhibitor, that efficiently reduces rhein-induced apoptosis by 77% at 0.01 mM resulting in 17% apoptotic cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41000
-
 x * 41000 + x * 43000, cleaved caspase-8, SDS-PAGE Homo sapiens
43000
-
 x * 41000 + x * 43000, cleaved caspase-8, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspases 3, 8 and 9 are essential to rhein-induced apoptosis, inhibitors of caspases 3, 8 and 9 are efficiently blocked by rhein-induced apoptosis in TNF-alpha-treated human aortic smooth muscle cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is cleaved to 41 and 43 kDA fragments, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspases 3, 8 and 9 are essential to rhein-induced apoptosis, inhibitors of caspases 3, 8 and 9 are efficiently blocked by rhein-induced apoptosis in TNF-alpha-treated human aortic smooth muscle cells, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 41000 + x * 43000, cleaved caspase-8, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
caspase 8
-
 Homo sapiens
More the enzyme belongs to the family of cysteine proteases known as caspases Homo sapiens