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Literature summary for 3.4.22.61 extracted from

  • Albrecht, E.A.; Sarma, J.V.; Ward, P.A.
    Activation by C5a of endothelial cell caspase 8 and cFLIP (2009), Inflamm. Res., 58, 30-37.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
complement factor 5a increases caspase-8 activity and expression level of procaspase-8, and increases caspase 8 homologue FLICE-inhibitory protein, cFLIP, activation, C5a stimulation initiated cFLIP cleavage, which increased the 43 kDa active fragment, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cFLIP a caspase 8 homologue, FLICE-inhibitory protein, acts as a competitive inhibitor to caspase 8 by blocking caspase 8 binding to the death induced signaling complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase 8 activation induced by C5a leads to cell death if protein synthesis of antiapoptotic proteins are blocked ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is cleaved to active caspase-8 producing active p41/p43 fragments Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
umbilical vein endothelial cell primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase 8 activation induced by C5a leads to cell death if protein synthesis of antiapoptotic proteins are blocked Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
caspase 8
-
 Homo sapiens
cysteine aspartic acid protease 8
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens