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Literature summary for 3.4.22.61 extracted from

  • Jin, D.; Ojcius, D.M.; Sun, D.; Dong, H.; Luo, Y.; Mao, Y.; Yan, J.
    Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways (2009), Infect. Immun., 77, 799-809.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information Leptospira interrogans induces apoptosis in macrophages and hepatocytes via caspase-8- and caspase-3-dependent pathways Mus musculus
additional information Leptospira interrogans induces apoptosis in macrophages and hepatocytes via caspase-8- and caspase-3-dependent pathways Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-IETD-fluoromethyl ketone effects on the activation of caspase-8 through cell infection with Leptospira interrogans Homo sapiens
N-carbobenzyloxy-IETD-fluoromethyl ketone effects on the activation of caspase-8 through cell infection with Leptospira interrogans Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-3 is an initiator caspase. Increased caspase-8 activation is involved in initiation of apoptosis, inhibition of caspase-8 impairs Leptospira interrogans-induced caspase-3 and -6 activation, as well as PARP and lamin A/C cleavage and apoptosis, overview. Leptospira interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADD-caspase-8-dependent pathway, independently of mitochondrial cytochrome c-caspase-9-dependent signaling, regulation, overview ?
-
?
additional information Mus musculus caspase-3 is an initiator caspase. Increased caspase-8 activation is involved in initiation of apoptosis, inhibition of caspase-8 impairs Leptospira interrogans-induced caspase-3 and -6 activation, as well as PARP and lamin A/C cleavage and apoptosis, overview. Leptospira interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADD–caspase-8-dependent pathway, independently of mitochondrial cytochrome c–caspase-9-dependent signaling, regulation, overview ?
-
?
procaspase-3 + H2O Mus musculus in some cells, active caspase-8 is sufficient to activate caspase-3 directly. In other cells, however, caspase-8 indirectly mediates caspase-3 activation by cleaving the proapoptotic Bcl-2 family member Bid, which induces mitochondrial cytochrome c release caspase-3 + ?
-
?
procaspase-3 + H2O Homo sapiens in some cells, active caspase-8 is sufficient to activate caspase-3 directly. In other cells, however, caspase-8 indirectly mediates caspase-3 activation by cleaving the proapoptotic Bcl-2 family member Bid, which induces mitochondrial cytochrome c release caspase-3 + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
hepatocyte
-
Mus musculus
-
hepatocyte
-
Homo sapiens
-
J-774A.1 cell
-
Mus musculus
-
macrophage peritoneal Mus musculus
-
macrophage peritoneal Homo sapiens
-
umbilical vein endothelial cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mus musculus
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Ile-Glu(OMe)-Thr-Asp(OMe)-7-amido-4-trifluoromethylcoumarin + H2O
-
Mus musculus acetyl-Ile-Glu(OMe)-Thr-Asp(OMe) + 7-amino-4-trifluoromethylcoumarin
-
?
acetyl-Ile-Glu(OMe)-Thr-Asp(OMe)-7-amido-4-trifluoromethylcoumarin + H2O
-
Homo sapiens acetyl-Ile-Glu(OMe)-Thr-Asp(OMe) + 7-amino-4-trifluoromethylcoumarin
-
?
additional information caspase-3 is an initiator caspase. Increased caspase-8 activation is involved in initiation of apoptosis, inhibition of caspase-8 impairs Leptospira interrogans-induced caspase-3 and -6 activation, as well as PARP and lamin A/C cleavage and apoptosis, overview. Leptospira interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADD-caspase-8-dependent pathway, independently of mitochondrial cytochrome c-caspase-9-dependent signaling, regulation, overview Homo sapiens ?
-
?
additional information caspase-3 is an initiator caspase. Increased caspase-8 activation is involved in initiation of apoptosis, inhibition of caspase-8 impairs Leptospira interrogans-induced caspase-3 and -6 activation, as well as PARP and lamin A/C cleavage and apoptosis, overview. Leptospira interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADD–caspase-8-dependent pathway, independently of mitochondrial cytochrome c–caspase-9-dependent signaling, regulation, overview Mus musculus ?
-
?
procaspase-3 + H2O activation Mus musculus caspase-3 + ?
-
?
procaspase-3 + H2O activation Homo sapiens caspase-3 + ?
-
?
procaspase-3 + H2O in some cells, active caspase-8 is sufficient to activate caspase-3 directly. In other cells, however, caspase-8 indirectly mediates caspase-3 activation by cleaving the proapoptotic Bcl-2 family member Bid, which induces mitochondrial cytochrome c release Mus musculus caspase-3 + ?
-
?
procaspase-3 + H2O in some cells, active caspase-8 is sufficient to activate caspase-3 directly. In other cells, however, caspase-8 indirectly mediates caspase-3 activation by cleaving the proapoptotic Bcl-2 family member Bid, which induces mitochondrial cytochrome c release Homo sapiens caspase-3 + ?
-
?

Synonyms

Synonyms Comment Organism
cysteine aspartic acid-specific protease
-
Mus musculus
cysteine aspartic acid-specific protease
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus
7.4
-
assay at Homo sapiens