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Literature summary for 3.4.22.61 extracted from

  • Fuccio, C.; Luongo, C.; Capodanno, P.; Giordano, C.; Scafuro, M.A.; Siniscalco, D.; Lettieri, B.; Rossi, F.; Maione, S.; Berrino, L.
    A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice (2009), Eur. J. Pharmacol., 603, 42-49.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-8 expression is increased in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve, prevented by ozone Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information high doses of ozone inhibit caspase-8 overexpression Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-8 is a pro-apoptotic caspase, whose expression is increased in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve, prevented by ozone, regulation, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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 Mus musculus
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sciatic nerve caspase-8 expression is increased in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve, prevented by ozone Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8 is a pro-apoptotic caspase, whose expression is increased in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve, prevented by ozone, regulation, overview Mus musculus ?
-
 ?