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Literature summary for 3.4.22.61 extracted from

  • Huang, S.; Okumura, K.; Sinicrope, F.A.
    BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells (2009), Clin. Cancer Res., 15, 150-159.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information obatoclax enhances TRAIL-mediated apoptosis, which is accompanied by activation of caspase-8, -9, and -3 and cleavage of Bid. A feedback amplification loop mediated by caspase-3 may contribute to activation of caspase-8 and Bid, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information Bid knockdown by lentiviral shRNA in PANC-1cells markedly attenuates caspase cleavage of caspase-8, -9, and -3 and cytotoxicity induced by obatoclax plus TRAIL Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bid peptide + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BxPC-3 cell
-
Homo sapiens
-
PANC-1 cell
-
Homo sapiens
-
pancreatic cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bid peptide + H2O
-
Homo sapiens ?
-
?