Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | obatoclax enhances TRAIL-mediated apoptosis, which is accompanied by activation of caspase-8, -9, and -3 and cleavage of Bid. A feedback amplification loop mediated by caspase-3 may contribute to activation of caspase-8 and Bid, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Bid knockdown by lentiviral shRNA in PANC-1cells markedly attenuates caspase cleavage of caspase-8, -9, and -3 and cytotoxicity induced by obatoclax plus TRAIL | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bid peptide + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BxPC-3 cell | - |
Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bid peptide + H2O | - |
Homo sapiens | ? | - |
? |