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Literature summary for 3.4.22.61 extracted from

  • Bonofiglio, D.; Gabriele, S.; Aquila, S.; Qi, H.; Belmonte, M.; Catalano, S.; Ando, S.
    Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells (2009), Breast Cancer Res. Treat., 113, 423-434.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information rosiglitazone, i.e. BRL, induces procaspase-8 cleavage and activation to caspase-8 leading to apoptosis in breast cancer cells. Rosiglitazone transactivates the FasL promoter gene in a peroxisome proliferator-activated receptor gamma PPARgamma-dependent manner Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Fas ligand, a type II transmembrane protein expressed on the surface of cells, induces apoptotic cell death by binding to its receptor Fas, resulting in recruitment of the Fas-associated death domain protein and caspase 8 zymogens to the receptor and the formation of the death-inducing signalling complex, after which the caspases cascade can be activated. Defects in the Fas/FasL apoptotic signalling pathway provide a survival advantage to cancer cells and may be implicated in tumorigenesis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is cleaved to active caspase-8 and an 11-kDa fragment Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Fas ligand, a type II transmembrane protein expressed on the surface of cells, induces apoptotic cell death by binding to its receptor Fas, resulting in recruitment of the Fas-associated death domain protein and caspase 8 zymogens to the receptor and the formation of the death-inducing signalling complex, after which the caspases cascade can be activated. Defects in the Fas/FasL apoptotic signalling pathway provide a survival advantage to cancer cells and may be implicated in tumorigenesis Homo sapiens ?
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 ?