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Literature summary for 3.4.22.61 extracted from

  • Chen, X.Y.; Yang, H.X.; Qu, S.F.; Liu, J.; Lv, P.; Xu, J.P.; Xu, K.S.
    Involvement of p38 and c-Jun N-terminal protein kinase in cardiotoxin III-induced apoptosis of K562 cells (2009), Biol. Pharm. Bull., 32, 583-588.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
additional information CTX III, from crude venom of Naja naja atra, induces the activation of caspase-8 as part of the caspase-8-dependent Bid-Bax pathway, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bid peptide + H2O Homo sapiens CTX III, from crude venom of Naja naja atra, inhibits proliferation of human leukemia K562 cells by G2/M phase arresting and apoptosis which is associated with the activation of caspase-8 and cytochrome c release as well as the p38 and c-Jun N-terminal protein kinase phosphorylation signaling pathway in vitro and in vivo, caspase-8-dependent Bid-Bax pathway, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
K-562 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bid peptide + H2O
-
 Homo sapiens ?
-
 ?
Bid peptide + H2O CTX III, from crude venom of Naja naja atra, inhibits proliferation of human leukemia K562 cells by G2/M phase arresting and apoptosis which is associated with the activation of caspase-8 and cytochrome c release as well as the p38 and c-Jun N-terminal protein kinase phosphorylation signaling pathway in vitro and in vivo, caspase-8-dependent Bid-Bax pathway, overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens